The main objective of the present investigation was to formulate and evaluate the pulsatile drug delivery system for anti-diabetic drug miglitol to control the increased blood glucose level after food consumption in diabetic patient by allowing the drug to release immediately after meals. Press coated tablets of miglitol were prepared by compression coating immediate release miglitol core tablets with hydrophilic and hydrophobic polymer in different ratios. The ideal concentration of hydrophilic and hydrophobic polymers were selected based on the invitro drug release profile and desired lag time of 4 hrs. The Invitro release studies were carried out for the formulated miglitol press coated tablets using different buffer solutions such as pH 1.2,7.4 and 6.8.The invitro drug release profile of miglitol press coated tablets containing 25mg of glyceryl behenate and 175 mg of L-HPC exhibited a time period of 4 hrs without drug release (lag time) followed by a rapid release of drug. Hence the developed formulation was found to be suitable for the diabetic patient to manage the blood glucose levels which are high after food consumption.
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